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Staff list

RNDr. Bohumír Grüner, CSc.

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Phone: 311236938
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Department: Department of Syntheses
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List of publications: www.lib.cas.cz/arl/bibliografie/ asep/uach-t/0102653
Research insterest
synthetic chemistry of boranes, carboranes and metallacarboranes with particular interest in substitution reactions, chiral species, supraicosahedral systems and biologically active compounds; medicinal chemistry of boron compounds, as, e.g., design and synthesis of cluster-based specific inhibitors of HIV-Protease and Carbonic Anhydrase CA-IX.

Projekty

 Number  Title  Years
21-14409S Exopolyhedral substitutions at metallacarborane cages and their stereochemistry 2021-2023 
19-04630S Tuning of electrochemical properties of boron polyhedral by advanced substitutions towards their use in bioconjugates; systematic basic research 2019-2021 

Publikace

2022
BOGUCKA-KOCKA, A., KOLODZIEJ, P., MAKUCH-KOCKA, A., ROZYCKA, D., RYKOWSKI, S., NEKVINDA, Jan, GRÜNER, Bohumír, OLEJNICZAK, A. Nematicidal activity of naphthalimide-boron cluster conjugates. Chemical Communications. 2022, 58(15), 2528-2531
EL ANWAR, Suzan, PAZDEROVÁ, Lucia, BAVOL, Dmytro, BAKARDJIEV, Mario, RŮŽIČKOVÁ, Z., HORÁČEK, O., FOJT, Lukáš, KUČERA, R., GRÜNER, Bohumír. Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials. Chemical Communications. 2022, 58(15), 2572-2575
2021
BEDNARSKA-SZCZEPANIAK, K., PRZELAZLY, E., KANIA, K. D., SZWED, M., LITECKÁ, Miroslava, GRÜNER, Bohumír, LESNIKOWSKI, Z. J. Interaction of adenosine, modified using carborane clusters, with ovarian cancer cells: A new anticancer approach against chemoresistance. Cancers (Basel). 2021, 13(15)), 3855
DISTLER, P., MINDOVÁ, M., ŠEBESTA, J., GRÜNER, Bohumír, BAVOL, Dmytro, EGBERINK, H., VERBOOM, W., BABAIN, V.A., JOHN, J. Stability of Different BTBP and BTPhen Extracting or Masking Compounds against ?radiation. ACS Omega. 2021, 6(4), 26416-26427
HORÁČEK, O., PAPAJOVÁ-JANETKOVÁ, M., GRÜNER, Bohumír, LOCHMAN, L., ŠTĚRBOVÁ-KOVAŘÍKOVÁ, P., VESPALEC, Radim, KUČERA, R. The first chiral HPLC separation of dicarba-nido-undecarborate anions and their chromatographic behavior. Talanta. 2021, 222(JAN)), 121652
KUGLER, Michael, NEKVINDA, Jan, HOLUB, Josef, EL ANWAR, Suzan, DAS, V., ŠÍCHA, Václav, POSPÍŠILOVÁ, Klára, FÁBRY, M., KRÁL, V., BRYNDA, Jiří, KAŠIČKA, Václav, HAJDÚCH, M., ŘEZÁČOVÁ, Pavlína, GRÜNER, Bohumír. Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds. Chembiochem. 2021, 22(18), 2741-2761
SCHMIDT, H., WILDEN, A., MODOLO, G., BOSBACH, D., SANTIAGO-SCHÜBEL, B., HUPERT, M., MINCHER, B.J., MEZYK, S. P., ŠVEHLA, Jaroslav, GRÜNER, Bohumír, EKBERG, C. Gamma and pulsed electron radiolysis studies of CyMe4BTBP and CyMe4BTPhen: Identification of radiolysis products and effects on the hydrometallurgical separation of trivalent actinides and lanthanides. Radiation Physics and Chemistry. 2021, 189(DEC)), 109696
ŠOLÍNOVÁ, Veronika, BRYNDA, Jiří, ŠÍCHA, Václav, HOLUB, Josef, GRÜNER, Bohumír, KAŠIČKA, Václav. Determination of acidity constants, ionic mobilities, and hydrodynamic radii of carborane-based inhibitors of carbonic anhydrases by capillary electrophoresis. Electrophoresis. 2021, 42(7/8), 910-919
2020
BAKARDJIEV, Mario, EL ANWAR, Suzan, BAVOL, Dmytro, RŮŽIČKOVÁ, Z., GRÜNER, Bohumír. Focus on Chemistry of the 10-Dioxane-nido-7,8-dicarba-undecahydrido Undecaborate Zwitterion, Exceptionally Easy Abstraction of Hydrogen Bridge and Double-Action Pathways Observed in Ring Cleavage Reactions with OH- as Nucleophile. Molecules. 2020, 25(4)), 814
DVOŘANOVÁ, J., KUGLER, Michael, HOLUB, Josef, ŠÍCHA, Václav, DAS, V., NEKVINDA, Jan, EL ANWAR, Suzan, HAVRÁNEK, M., POSPÍŠILOVÁ, Klára, FÁBRY, M., KRÁL, V., MEDVEDÍKOVÁ, M., MATĚJKOVÁ, Stanislava, LIŠKOVÁ, B., GURSKÁ, S., DŽUBÁK, P., BRYNDA, J., HAJDÚCH, M., GRÜNER, Bohumír, ŘEZÁČOVÁ, Pavlína. Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. European Journal of Medicinal Chemistry. 2020, 200(Aug 15)), 112460
EL ANWAR, Suzan, RŮŽIČKOVÁ, Z., BAVOL, Dmytro, FOJT, Lukáš, GRÜNER, Bohumír. Tetrazole Ring Substitution at Carbon and Boron Sites of the Cobalt Bis(dicarbollide) Ion Available via Dipolar Cycloadditions. Inorganic Chemistry. 2020, 59(23), 17430-17442
FOJT, Lukáš, GRÜNER, Bohumír, ŠÍCHA, Václav, NEKVINDA, Jan, VESPALEC, Radim, FOJTA, Miroslav. Electrochemistry of icosahedral cobalt bis(dicarbollide) ions and their carbon and boron substituted derivatives in aqueous phosphate buffers. Electrochimica acta. 2020, 342(MAY 10 2020)), 136112
FOJT, Lukáš, NEKVINDA, Jan, EL ANWAR, Suzan, GRÜNER, Bohumír, HAVRAN, Luděk, FOJTA, Miroslav. Simple Electrochemical Characterization of ortho-carborane and Some of its Exo-skeletal Derivatives. Electroanalysis. 2020, 32(8), 1859-1866
KUGLER, Michael, HOLUB, Josef, BRYNDA, Jiří, POSPÍŠILOVÁ, Klára, EL ANWAR, Suzan, BAVOL, Dmytro, HAVRÁNEK, M., KRÁL, V., FÁBRY, M., GRÜNER, Bohumír, ŘEZÁČOVÁ, Pavlína. The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. Journal of Enzyme Inhibition and Medicinal Chemistry. 2020, 35(1), 1800-1810
NEKVINDA, Jan, KUGLER, Michael, HOLUB, Josef, EL ANWAR, Suzan, BRYNDA, Jiří, POSPÍŠILOVÁ, K., RŮŽIČKOVÁ, Z., ŘEZÁČOVÁ, Pavlína, GRÜNER, Bohumír. Direct Introduction of an Alkylsulfonamido Group on C-sites of Isomeric Dicarba-closo-dodecaboranes: The Influence of Stereochemistry on Inhibitory Activity against the Cancer-Associated Carbonic Anhydrase IX Isoenzyme. Chemistry - A European Journal. 2020, 26(69), 16541-16553
NEKVINDA, Jan, ROZYCKA, D., RYKOWSKI, S., WYSZKO, E., FEDORUK-WYSZOMIRSKA, A., GURDA, D., ORLICKA-PLOCKA, M., GIEL-PIETRASZUK, M., KILISZEK, A., RYPNIEWSKI, W., BACHORZ, R., WOJCIESZAK, J., GRÜNER, Bohumír, OLEJNICZAK, A. Synthesis of naphthalimide-carborane and metallacarborane conjugates: Anticancer activity, DNA binding ability. Bioorganic Chemistry. 2020, 94(JAN)), 103432
2019
ASSAF, K. I., BEGAJ, B., FRANK, A., NILAM, M., MOUGHARBEL, A. S., KORTZ, U., NEKVINDA, Jan, GRÜNER, Bohumír, GABEL, D., NAU, W. M. High-affinity binding of metallacarborane cobalt bis(dicarbollide) anions to cyclodextrins and application to membrane translocation. Journal of Organic Chemistry. 2019, 84(18), 11790-11798
EL ANWAR, Suzan, ASSAF, K. I., BEGAJ, B., SAMSONOV, M. A., RŮŽIČKOVÁ, Z., HOLUB, Josef, BAVOL, Dmytro, NAU, W. M., GABEL, D., GRÜNER, Bohumír. Versatile, one-pot introduction of nonahalogenated 2-ammonio-decaborate ions as boron cluster scaffolds into organic molecules, host-guest complexation with ?-cyclodextrin. Chemical Communications. 2019, 55(91), 13669-13672
GRÜNER, Bohumír, BRYNDA, Jiří, DAS, V., ŠÍCHA, Václav, ŠTĚPÁNKOVÁ, J., NEKVINDA, Jan, HOLUB, Josef, POSPÍŠILOVÁ, B., FÁBRY, Milan, PACHL, P., KRÁL, Vlastimil, KUGLER, M., MAŠEK, V., MEDVĚDIKOVÁ, M., MATĚJKOVÁ, S., NOVÁ, A., LIŠKOVÁ, B., GURSKÁ, S., DŽUBÁK, P., HAJDÚCH, M., ŘEZÁČOVÁ, Pavlína. Metallacarborane sulfamides: Unconventional, specific, and highly selective inhibitors of carbonic anhydrase IX. Journal of Medicinal Chemistry. 2019, 62(21), 9560-9575
KHAYDUKOVA, M., MILITSYN, D., KARNAUKH, M., GRÜNER, Bohumír, SELUCKÝ, P., BABAIN, V., WILDEN, A., KIRSANOV, D., LEGIN, A. Modified Diamide and Phosphine Oxide Extracting Compounds as Membrane Components for Cross-Sensitive Chemical Sensors. Chemosensors. 2019, 7(3)), 41
SRB, Pavel, SVOBODA, Michal, BENDA, L., LEPŠÍK, Martin, TARÁBEK, Ján, ŠÍCHA, Václav, GRÜNER, Bohumír, GRANTZ ŠAŠKOVÁ, Klára, BRYNDA, Jiří, ŘEZÁČOVÁ, Pavlína, KONVALINKA, Jan, VEVERKA, Václav. Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy. Physical Chemistry Chemical Physics. 2019, 21(10), 5661-5673
VAŇKOVÁ, E., LOKOČOVÁ, K., MAŤÁTKOVÁ, O., KŘÍŽOVÁ, I., MASÁK, J., GRÜNER, Bohumír, KAULE, P., ČERMÁK, J., ŠÍCHA, V. Cobalt bis-dicarbollide and its ammonium derivatives are effective antimicrobial and antibiofilm agents. Journal of Organometallic Chemistry. 2019, 899(OCT)), 120891
2018
EL ANWAR, Suzan, HOLUB, Josef, TOK, Oleg L., JELÍNEK, T., RŮŽIČKOVÁ, Z., FOJT, Lukáš, ŠOLÍNOVÁ, Veronika, KAŠIČKA, Václav, GRÜNER, Bohumír. Synthesis and selected properties of nonahalogenated 2-ammonio-decaborate anions and their derivatives substituted at N-centre. Journal of Organometallic Chemistry. 2018, 865(SI), 189-199
HALLERÖD, J., EKBERG, C., AUTHEN, T., BERTOLO, L., LIN, M., GRÜNER, Bohumír, ŠVEHLA, Jaroslav, WAGNER, C., GEIST, A., PANAK, P., ANEHEIM, E. On the Basic Extraction Properties of a Phenyl Trifluoromethyl Sulfone-Based GANEX System Containing CyMe4-BTBP and TBP. Solvent Extraction and Ion Exchange. 2018, 36(4), 360-372
NEKVINDA, Jan, GRÜNER, Bohumír, GABEL, D., NAU, W. M., ASSAF, K. I. Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins. Chemistry - A European Journal. 2018, 24(49), 12970-12975
2017
HOLUB, Josef, EL ANWAR, Suzan, JELÍNEK, T., FOJT, Lukáš, RŮŽIČKOVÁ, Z., ŠOLÍNOVÁ, Veronika, KAŠIČKA, Václav, GABEL, D., GRÜNER, Bohumír. Polyhalogenated Decaborate and 1-Ammoniododecaborate Ions: An Improved Synthesis with Elemental Halogens, and Physicochemical and Chemical Properties. European Journal of Inorganic Chemistry. 2017, 2017(38/39), 4499-4509
2016
FOJT, Lukáš, FOJTA, Miroslav, HOLUB, Josef, GRÜNER, Bohumír, VESPALEC, Radim. Electrochemistry of different boranes, carbaboranes and their exo-skeletal hydroxy derivatives at the graphite carbon electrode in aqueous phosphate buffers. Electrochimica acta. 2016, 205(JUL 2016), 8-14
2015
DISTLER, P., KONDÉ, J., JOHN, J., HÁJKOVÁ, Zuzana, ŠVEHLA, Jaroslav, GRÜNER, Bohumír. Characterization of solvents containing CyMe4-BTPhen in selected cyclohexanone-based diluents after irradiation by accelerated electrons. Nukleonika. 2015, 60(4), 885-891
GRÜNER, Bohumír, ŠÍCHA, Václav, HNYK, Drahomír, LONDESBOROUGH, Michael Geoffrey Stephen, CÍSAŘOVÁ, I. The Synthesis and Structural Characterization of Polycyclic Derivatives of Cobalt Bis(dicarbollide)(1(-)). Inorganic Chemistry. 2015, 54(7), 3148-3158
KAMENÍK, Jan, ŠEBESTA, F., JOHN, J., BÖHMER, V., RUDZEVICH, V., GRÜNER, Bohumír. Polyacrylonitrile based composite materials with extracting agents containing chemically bonded CMPO groups for separation of actinoids. Journal of Radioanalytical and Nuclear Chemistry. 2015, 304(1), 313-319
NEKVINDA, Jan, ŠVEHLA, Jaroslav, CÍSAŘOVÁ, I., GRÜNER, Bohumír. Chemistry of cobalt bis(1,2-dicarbollide) ion; the synthesis of carbon substituted alkylamino derivatives from hydroxyalkyl derivatives via methylsulfonyl or p-toluenesulfonyl esters. Journal of Organometallic Chemistry. 2015, 798(1), 112-120