The presentation "The impact of environmental pollution on oxidative stress in mothers/newborns" will be introduced by Dr. Antonín Ambrož from the Institute of Experimental Medicine of the CAS.
The 42nd NARECOM will take place on Wednesday, February 5, 2025, at 2:30. p.m.
Join Zoom Meeting: https://cesnet.zoom.us/j/93563225963
Abstract:
The project “Healthy Aging in Industrial Environment” (HAIE) was carried out in 2018-2022. The partial aim of the study was to analyze contaminants that affect oxidative DNA damage and lipid peroxidation in non-smoking mothers and their newborns. 147 pairs of mothers/newborns originated from Ceske Budejovice (CB; an agricultural region) and 201 pairs were recruited from Karvina (an industrial region). Personal and medical data, external (PM2.5, B[a]P) and internal (PCBs, OCPs, BFRs, PFASs and OH-PAHs) exposures, antioxidant mechanisms (SOD, CAT, GPx and ORAC), and cytokines concentrations (IL-1β, IL-6) were investigated as parameters potentially affecting the markers of DNA oxidation (8-oxo-7,8-dihydro-2’-deoxyguanosine) and lipid peroxidation (15-F2t-isoprostane).
